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- ************************
- * TEA domain signature *
- ************************
-
- The TEA domain [1] is a DNA-binding region of about 66 to 68 amino acids which
- has been found in the N-terminal section of the following nuclear regulatory
- proteins:
-
- - Mammalian enhancer factor TEF-1. TEF-1 can bind to two distinct sequences
- in the SV40 enhancer and is a transcriptional activator.
- - Drosophila scalloped protein (gene sd), a probable transcription factor
- that functions in the regulation of cell-specific gene expression during
- Drosophila development, particularly in the differentiation of the nervous
- system [2].
- - Emericella nidulans regulatory protein abaA. AbaA is involved in the
- regulation of conidiation (asexual spore); its expression leads to the
- cessation of vegetative growth.
- - Yeast trans-acting factor TEC1. TEC1 is involved in the activation of the
- Ty1 retrotransposon.
-
- As a signature pattern, we have used positions 39 to 67 of the TEA domain.
-
- -Consensus pattern: G-R-N-E-L-I-x(2)-Y-I-x(3)-T-x(3)-R-T-[RK](2)-Q-[LIVM]-S-S-
- H-[LIVM]-Q-V
- -Sequences known to belong to this class detected by the pattern: ALL.
- -Other sequence(s) detected in SWISS-PROT: NONE.
- -Last update: October 1993 / Text revised.
-
- [ 1] Buerglin T.R.
- Cell 66:11-12(1991).
- [ 2] Campbell S.D., Inamdar M., Rodrigues V., Raghavan V., Palazzolo M.,
- Chovnick A.
- Genes Dev. 6:367-379(1992).
-